WHO pointers mandate that sterility test isolators go through thorough revalidation at the very least annually, or maybe more regularly if sizeable changes or routine maintenance things to do have occurred. Glove ports are positioned ergonomically and are validated with leak/penetration tests. VHP programs are built-in with cycle parameters https://medium.com/@tailinscitech/applications-and-benefits-of-tailin-containment-isolator-for-handling-high-potency-materials-8c66a55dbcf7