I do not know why rue impacts using tobacco. It had been counter-intuitive for me also. I don't know the mechanisms involved. But it really is completely accurate. I have not tried using it, but I am aware Individuals who have, and it's perfectly documented on the internet. I imagine https://mnobookmarks.com/story19930431/the-fact-about-ayahuasca-drug-where-to-buy-that-no-one-is-suggesting