You will find a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to lessen afferent soreness transmission and produce analgesia. Hence, drugs like clonidine that target alpha-2 receptors can affect the transmission of soreness. Clonidine is dispersed in breast milk; https://thebookmarknight.com/story19735018/onolidine-an-overview