Pentobarbital will minimize the extent or influence of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent CYP3A4 inducers may well lower midostaurin concentrations causing minimized efficacy. pentobarbital will lower the level or outcome of dapsone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Un... https://milovanw580dil7.vigilwiki.com/user