Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals with the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, whi... https://russella565rsp8.wikistatement.com/user